A glicoproteinap gpp foi descrita pela primeira vez em 1976 como uma. Pglycoprotein 1 also known as multidrug resistance protein 1 mdr1 or atp binding cassette. O papel da glicoproteina p nas interacoes farmacofarmaco. Free le basi della farmacologia pdf download bernardshaw. Read online or download ebook le basi della farmacologia pdf free in pdf, epub, mobi, doc, and txt format for free. Veja gratis o arquivo farmacologia farmacocinetica e farmacodinamica. Glicoproteina p o atpasi trasportatrice di farmaci. P gp has been reported to affect the pharmacokinetics of structurally and pharmacologically diverse substrates. Glicoproteinap, resistencia a multiplas drogas mdr e relacao. Pgp has been reported to affect the pharmacokinetics of structurally and pharmacologically diverse substrates. Initially p gp was identified by its overexpression in multidrug resistant tumor cells. Abstract pglycoprotein pgp, a protein encoded by the multidrug resistance gene 1 mdr1, functions as a transporter that promotes cellular efflux of a. Universita degli studi di siena dipartimento di farmacologia g.
Glicoproteinap, resistencia a multiplas drogas mdr e. Falando sobre absorcao, distribuicao, metabolismo e excrecao. Initially pgp was identified by its overexpression in multidrug resistant tumor cells. Parte estos y sus metabolitos pueden excretarse en heces 6.
P glycoprotein 1 permeability glycoprotein, abbreviated as p gp or pgp also known as multidrug resistance protein 1 mdr1 or atpbinding cassette subfamily b member 1 abcb1 or cluster of differentiation 243 cd243 is an important protein of the cell membrane that pumps many foreign substances out of cells. Pgycoprotein is porposed to modulate and determine the existence of peaks in the. Pgp is also expressed in a wide range of normal tissues including liver. Results showed a polarized permeation in the basaltoapical direction, reduced by inhibitors of the transporter 0. Inhibition or induction of pgp expression by coadministered drugs, food andor natural products may result in pharmacokinetic interactions that lead to unwanted side effects andor decreased effectiveness of treatment. Temario completo farmacologia eui sant pau 20112012. Papel da glicoproteinap na farmacocinetica e nas interacoes. P glycoprotein p gp is a transporter protein associated with multidrug resistance to certain anticancer drugs mdr. P gp is also expressed in a wide range of normal tissues including liver, intestines, bloodbrain barrier and kidneys. Inhibition or induction of p gp expression by coadministered drugs, food andor natural products may result in pharmacokinetic interactions that lead to unwanted side effects andor decreased effectiveness of treatment. Farmacologia antigenos cd proteinas humanas transportadores abc. Pglycoprotein 1 permeability glycoprotein, abbreviated as pgp or pgp also known as multidrug resistance protein 1 mdr1 or atpbinding cassette subfamily b member 1 abcb1 or cluster of differentiation 243 cd243 is an important protein of the cell membrane that pumps many foreign substances out of cells. Review multidrug resistance mdr1 gene and pglycoprotein.
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